Carboxylic acids and derivatives
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.06% | 50 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment that exhibits solid-state fluorescence with excitation/emission at 411 nm/512 nm. This product is available as a commercial colorant.
- Yellow bis-azomethine pigment
- Excitation/emission: 411 nm/512 nm
- Exhibits solid-state fluorescence
- Available as a commercial colorant
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 10mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Medchemexpress LLC VNT-101 | 2894060-67-2 | 99.5% | 456.41 | 5 MG
VNT-101 is an orally active influenza A (IAV) inhibitor that disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex. It exhibits potent antiviral activity across multiple influenza A subtypes and robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. It can be used for the study of influenza A infection.
- Orally active influenza A (IAV) inhibitor.
- Disrupts NP-NP PPI to block NP oligomerization.
- Destabilizes the viral ribonucleoprotein (RNP) complex.
- Potent antiviral activity across multiple influenza A subtypes.
- Exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay.
- Demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus.
Medchemexpress LLC Ethyl Lauroyl Argina 5g
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative[1]
Medchemexpress LLC Rhodamine 101 chloride | 64339-18-0 | 527.05 g/mol | C32H31ClN2O3 | 10 MG
Rhodamine 101 chloride is a bright xanthene-class fluorescent dye with excitation and emission maxima at 565 nm and 595 nm, respectively. It is used for fluorescence microscopy, cellular staining, and as a red-spectrum reference standard. The solid is supplied in small laboratory pack sizes and should be stored protected from light and moisture; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Excitation 565 nm and emission 595 nm.
- Suitable for fluorescence microscopy and cellular staining.
- Useful as a reference standard in red-spectrum labeling.
- Available in small lab pack sizes, including 10 mg.
- Store sealed, protected from moisture and light.
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | 95.0% | 563.51 | 25 MG
Rhodamine 101 hydrochloride is a fluorescent dye. It is known for its bright fluorescence and specific excitation and emission characteristics.
- Exhibits bright fluorescence
- Excitation maxima at 565 nm
- Emission maxima at 595 nm.
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | MFCD00210089 | >=95% | 563.51 | 5 MG
Rhodamine 101 chloride (Rhodamine 640 chloride) hydrochloride is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.
- For research use only.
- We do not sell to patients.
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 1mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 50 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It demonstrates cellular effects on HEK293 cells by inhibiting human EAAT1. This product is for research use only.
- Acts as an EAAT1 inhibitor
- Demonstrates cellular effects on HEK293 cells
- Inhibits human EAAT1 anion currents
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 25 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It is for research use only.
- Inhibits EAAT1 anion currents in a concentration-dependent manner
- Suitable for research applications
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC Sodium lauroyl glutamate | 29923-31-7 | 95.8% | 1 G
Sodium lauroyl glutamate is an anionic amino acid surfactant used primarily in cleaning products. It is considered a mild surfactant with low irritation to nude mouse skin, exhibiting a pH value of 5.41. It also has potential for irritant contact dermatitis and possible anti-irritating effects in surfactant mixtures on human skin.
- Anionic amino acid surfactant
- Mild surfactant properties
- Ideal for cleaning product formulations
- Low irritation potential
- pH value of 5.41